Effects
of Coenzyme Q10 in Early Parkinson Disease Evidence of Slowing of the Functional
Decline
Archives of Neurology
06/11/2002
Sommario
Il coenzima Q10, una delle sostanza fondamentali per la produzione dell'energia
nella cellula, è stato somministrato ad alte dosi in pazienti sofferenti di
Malattia di Parkinson in forma iniziale. Il trattamento con il coenzima Q10 è
stato ben tollerato. Dopo sedici mesi di terapia i pazienti evidenziavano una
minore disabilità rispetto a quelli che avevano assunto il placebo. La novità
dello studio è rappresentata dall'alto dosaggio di coenzima Q 10 assunto.
Probabilmente a questi dosaggi la sostanza riesce a raggiungere i neuroni
sofferenti.
Coenzyme Q10 appears to slow the progressive deterioration of
function in Parkinson's Disease, say researchers.
This is the promising find of a multicentre, randomized, parallel-group,
placebo-controlled, double-blind, dosage-ranging trial of 80 patients with early
Parkinson's disease who did not require treatment. The patients received either
placebo or coenzyme Q10 at dosages of 300, 600 or 1200 mg/d.
Clifford Shults, MD, said, "Coenzyme Q10 was safe and well
tolerated at dosages of up to 1200 mg/d. Less disability developed in subjects
assigned to coenzyme Q10 than in those assigned to placebo." He
added that the benefit was greatest in subjects receiving the highest dosage.
" Coenzyme Q10 appears to slow the progressive deterioration of
function in Parkinson's disease, but these results need to be confirmed in a
larger study." Dr Shults is based at the Department of Neurosciences,
University of California, Dan Diego, La Jolla California and was lead
investigator of the study.
The subjects underwent evaluation with the Unified Parkinson Disease Rating
Scale at the screening, baseline, and at periods up to 16 months later. The
adjusted mean total Unified Parkinson Disease Rating Scale was +11.99 for the
placebo group, +8.81 for the 300-mg/d group, +10.82 for the 600-mg/d group, and
6.69 for the 1200-mg/d group.
Archives of Neurology 2002;59(10):1541-1550.
"Effects
of Coenzyme Q10 in Early Parkinson Disease Evidence of Slowing of the Functional
Decline"
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