Pagine dedicate alla Neurologia per l'aggiornamento dei Colleghi e per informazioni sulle nuove terapie e descrizioni di patologie rivolte in modo comprensibile ai pazienti

                                                                                          Dott. Carlo Sebastiano Tadeo
                                                                                                Specialista Neurologia

ACE inibitore protegge dalla aterosclerosi

 

                           Iscrivetevi alle Newsletter                   

                                             Newsletter  

 

 

 Novità dai principali congressi e pubblicazioni scientifiche 

Journals neurology

Per prenotare una visita neurologica

Servizio Traduzione

Medline

Congressi e convegni

Malattie neurologiche

Ictus
Sclerosi Multipla
Alzheimer
Parkinson
Neuropatie ereditarie
Cefalee

 

 

Pubblicità e links utili

 

We subscribe to the HONcode principles of the HON Foundation. Click to verify. We subscribe to the HONcode principles. Verify here.

 

 

www.ilneurologo.com - Candidato al Premio Web Italia 2003

Ramipril Study Suggests Protection Against Progression of Atherosclerosis

NEW YORK, NY -- May 23, 2000 -- New findings reveal that ramipril, an angiotensin converting enzyme (ACE) inhibitor, "reduced the risk of serious cardiovascular events and suggest a vasculo-protective effect of ramipril, independent of blood pressure reduction," says Peter Sleight, MD.

Dr. Sleight, one of the study co-chairs of the HOPE trial (Heart Outcomes Prevention Evaluation), presented the findings at the American Society of Hypertension meeting. The study was a collaboration between the University of Oxford, in Oxford, UK, and McMaster University, in London, Ontario, Canada.

The HOPE trial was a study of 9,541 high-risk patients (older than 55 years) who were randomly given either ramipril (10 mg od) or vitamin E (400 mg od) over 18 months. The trial was stopped earlier than expected due to the significant benefit seen from ramipril.

In a sub-study of HOPE, called SECURE (Study to Evaluate Carotid Ultrasound changes with Ramipril and Vitamin E), carotid ultrasound progression of atherosclerosis was followed in the same high risk patients. They were randomly given 10 mg od of ramipril, 2.5mg od of ramipril, 400 mg od of vitamin E, or placebo.

Results of SECURE show that blood pressure was reduced by the same amount (4/2 mm Hg) by the two doses of ramipril. Progression of carotid atherosclerosis was significantly reduced by the higher ramipril dose. Vitamin E showed neither benefit nor harm.

"In both the SECURE and main HOPE study, there was a clear benefit from ramipril, even after adjustment for baseline blood pressure and change in blood pressure," Dr. Sleight said.

New sub-studies in diabetic patients also support a protective effect in the carotid wall independent of blood pressure reduction, he added.

 

Per ulteriori informazioni, contattare:

Il Neurologo con voi
Via Copernico 59/a Milano 20125
Tel: 03332699103
Posta elettronica: tadeo@ilneurologo.com

            

Spazio pubblicitario libero

 

Inviare a tadeo@ilneurologo.com un messaggio di posta elettronica contenente domande o commenti su questo sito Web.
Aggiornato il: 27 February 2001